John Jefferies, MD

John Jefferies, MD

Jay M. Sullivan Endowed Chair in Cardiovascular Medicine
Chief of Cardiology
University of Tennessee Health Science Center (UTHSC)
Co-Director, UT Methodist Institute for Cardiovascular Science
University of Tennessee Heart Institute
Memphis, TN

Related Videos

What surveillance strategies, in the context of cardiovascular disease, optimize early detection, assessment, and monitoring of patients with suspected or confirmed FD? Video

What surveillance strategies, in the context of cardiovascular disease, optimize early detection, assessment, and monitoring of patients with suspected or confirmed FD?

What is the spectrum of cardiovascular manifestations of FD? What is the age of onset? Why is it important that we recognize the cardiovascular clinical phenotypes—arrhythmias, hypertrophic cardiomyopathy, stroke, etc.—of FD? Video

What is the spectrum of cardiovascular manifestations of FD? What is the age of onset? Why is it important that we recognize the cardiovascular clinical phenotypes—arrhythmias, hypertrophic cardiomyopathy, stroke, etc.—of FD?

Although GI and dermatologic manifestations tend to dominate the clinical phenotype of FD in childhood, are there cardiovascular manifestations—i.e. arrhythmias—in this subgroup that might point to the disease? Video

Although GI and dermatologic manifestations tend to dominate the clinical phenotype of FD in childhood, are there cardiovascular manifestations—i.e. arrhythmias—in this subgroup that might point to the disease?

Given the new therapies—including chaperone therapy with migalastat and ERT—available for FD, why do you believe there should be a “call to action” among the CV community that would heighten awareness of this disease? Video

Given the new therapies—including chaperone therapy with migalastat and ERT—available for FD, why do you believe there should be a “call to action” among the CV community that would heighten awareness of this disease?

There is sometimes a preconception that women, who are “carriers” for FD, do not suffer from CV complications and the diagnosis is missed or delayed with adverse consequences. Can you elaborate on this? Video

There is sometimes a preconception that women, who are “carriers” for FD, do not suffer from CV complications and the diagnosis is missed or delayed with adverse consequences. Can you elaborate on this?

How does the pathophysiology of Fabry, as a lysosomal disorder, produce the wide range of CV manifestations that should alert physicians to suspect FD as an underlying cause for unexplained symptoms in men and women? Video

How does the pathophysiology of Fabry, as a lysosomal disorder, produce the wide range of CV manifestations that should alert physicians to suspect FD as an underlying cause for unexplained symptoms in men and women?

If initial genetic tests or the clinical picture—proteinuria, family history, no evidence of diabetes—suggest FD, what is the next level of diagnostic genetic tests, i.e. mutational testing, that should be performed? Video

If initial genetic tests or the clinical picture—proteinuria, family history, no evidence of diabetes—suggest FD, what is the next level of diagnostic genetic tests, i.e. mutational testing, that should be performed?

Are there prospective studies that, in fact, are designed to evaluate the effects of currently approved chaperone- and ERT-based treatments for FD on the progression of CV complications of FD? Video

Are there prospective studies that, in fact, are designed to evaluate the effects of currently approved chaperone- and ERT-based treatments for FD on the progression of CV complications of FD?

What are the CV manifestations of FD disease in the adult population and how does the triad of arrhythmias, early MI, and/or cardiomyopathy set into motion diagnostic tests and surveillance strategies to evaluate the presence of FD? Video

What are the CV manifestations of FD disease in the adult population and how does the triad of arrhythmias, early MI, and/or cardiomyopathy set into motion diagnostic tests and surveillance strategies to evaluate the presence of FD?