Claire Zar-Kessler, MD

Claire Zar-Kessler, MD

Medical Director, Pediatric Neurogastroenterology Program
Instructor, Harvard Medical School
Mass General Hospital for Children
Boston, MA

Related Videos

Other than ERT and chaperone therapy, what other pharmacologic interventions are effective and safe for treating the GI symptoms of FD? Video

Other than ERT and chaperone therapy, what other pharmacologic interventions are effective and safe for treating the GI symptoms of FD?

Based on Registry Data for Fabry Disease, what have we learned about the importance of GI symptoms—including gender-based differences—in the context of improving awareness of FD as a condition for which we should screen? Video

Based on Registry Data for Fabry Disease, what have we learned about the importance of GI symptoms—including gender-based differences—in the context of improving awareness of FD as a condition for which we should screen?

Can you focus on the earliest age group in which GI symptoms of FD can plausibly be detected? Video

Can you focus on the earliest age group in which GI symptoms of FD can plausibly be detected?

Can you discuss a specific adult patient who came to you with GI symptoms and confirmed Fabry Disease, in whom therapeutic intervention improved their GI manifestations and quality of life? Video

Can you discuss a specific adult patient who came to you with GI symptoms and confirmed Fabry Disease, in whom therapeutic intervention improved their GI manifestations and quality of life?

At what age can FD-consistent GI manifestations first emerge? What is the most frequent misdiagnosis of GI symptoms that, in retrospect, were the first signs of FD in an individual patient? Video

At what age can FD-consistent GI manifestations first emerge? What is the most frequent misdiagnosis of GI symptoms that, in retrospect, were the first signs of FD in an individual patient?

Since a heterogeneous range of GI symptomatology is associated with Fabry Disease, can you discuss the spectrum of symptoms that are encountered? Video

Since a heterogeneous range of GI symptomatology is associated with Fabry Disease, can you discuss the spectrum of symptoms that are encountered?

How often are GI symptoms the portal for entertaining and confirming the diagnosis of FD? Video

How often are GI symptoms the portal for entertaining and confirming the diagnosis of FD?

How does deficiency of the lysosomal enzyme, alpha-galactosidase A lead to GI symptoms? What is the GI-related pathobiology of Fabry Disease? Through what vascular, tissue, and neuropaths mechanisms does GL-3 accumulation cause GI symptoms? Video

How does deficiency of the lysosomal enzyme, alpha-galactosidase A lead to GI symptoms? What is the GI-related pathobiology of Fabry Disease? Through what vascular, tissue, and neuropaths mechanisms does GL-3 accumulation cause GI symptoms?

What are the specific GI symptoms encountered in patients with FD? And what specific symptom patterns should alert the clinician that FD should be excluded in the differential diagnosis? Video

What are the specific GI symptoms encountered in patients with FD? And what specific symptom patterns should alert the clinician that FD should be excluded in the differential diagnosis?